Research in the JKMS group

Our main interest is in molecular recognition: how to generate molecules that bind to others strongly and selectively with non-covalent interactions, and how to use non-covalent interactions to drive the self-assembly of complex structures.

For the first of these, we are developing Dynamic Combinatorial Chemistry, a method for combining the combinatorial synthesis and screening of host molecules into a single process. The approaches used in our group include the use of disulfide exchange (in collaboration with Dr. Sijbren Otto), thioester exchange, hydrazone exchange and metalloporphyrin-ligand coordination, and the use of computer simulations.

Please click on one of the links to find out more.